 Standings at start of day | Results for September 22, 1888 Des Moines @ Sioux City () |
| Game 433: Omaha @ Kansas City Kansas City 7, Omaha 1 Kansas City Times  | Game 434: Des Moines @ Sioux City Des Moines 1, Sioux City 0 Sioux City Journal  | Game 435: St. Paul @ Davenport St. Paul 7, Davenport 6 Quad City Times  | Game 436: Chicago @ Milwaukee Milwaukee 5, Chicago 3 Milwaukee Sentinel  |