 Standings at start of day | Results for May 22, 1888 Game 53: Omaha 7, Kansas City 1 |
| Game 53: Omaha @ Kansas City Omaha 7, Kansas City 1 Kansas City Times  | Game 54: Chicago @ Milwaukee Milwaukee 7, Chicago 2 Milwaukee Sentinel  | Game 55: Des Moines @ St. Louis St. Louis 6, Des Moines 3 St. Louis Republican  | Game 56: St. Paul @ Minneapolis St. Paul 7, Minneapolis 6 Minneapolis Star Tribune  |