The St. Louis Whites played in the Western Association for just part of one season, 1888, the first season for the league. The Western Association was formally organized in late October of 1887 with teams in Chicago, Des Moines, Kansas City, Omaha, Milwaukee, Minneapolis, St. Louis and St. Paul. The St. Louis club - the St. Louis Whites - was owned by Chris Von der Ahe, who also owned the St. Louis Browns, the three-peat defending Champions of the American Association. Von der Ahe owned 50% of the club, with Whites' manager Tom Loftus and Browns star Charlie Comiskey splitting the remaining 50%. After the Western Association was organized in the fall of 1887, Von der Ahe and Loftus went on a signing spree, signing several dozen players for the Browns and Whites for the 1888 season. The St. Louis Republican published a list of 28 players in December, 1887 signed for the two St. Louis ball clubs. By Spring Training, this list had expanded to encompass 31 players.
The St. Louis Whites played their first exhibition game against the St. Louis Browns on March 25, 1888. Their first championship game was April 28, 1888, against Milwaukee, at Sportsman’s Park. Their first 11 games were at home, while the Browns were on a road trip. Two games were cancelled due to the poor spring weather, and the attendance was poor at the games that were played. By late May, as the club returned from it first road trip, there were already reports that Von der Ahe was trying to sell the club. After at least one sale fell through in early June, he disbanded the club on June 24, 1888 and sold or released the remaining players (with a few being transferred to the Browns). The club lasted under two months, with a final record of 14-27 (the final two losses being forfeits).